GA/T 1925-2021 in English
VALIDForensic sciences-Examination methods for seven cathinones including 2-MMC in suspected drugs-GC and GC-MS
- Issued on:2021-10-14
- Implemented on:2022-05-01
- File Format:PDF
- Delivery:Via email within 1~3 business days
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Introduction
Analysis of the Standard Technical Framework
| Detection Objects | Qualitative Methods | Quantitative Methods | Detection Limit |
|---|---|---|---|
| 2-MMC and 7 Other Cathinones | LC-MS (High/Low Resolution) | LC External Standard Method | 10ng/mL |
Core Technology Innovations
The standard first established 3-CMC and 4-CMC used a formic acid-ammonium acetate buffer system (pH 3.5) to achieve baseline separation of seven structural analogs, with a relative deviation of column retention time ≤2.5%.
Key operating parameters
| Parameter type | LC conditions | MS conditions |
|---|---|---|
| Mobile phase | Formic acid-ammonium acetate/methanol gradient | ESI+ mode |
| Column | EclipsePlus C18（1.8μm,150mm） | |
| Characteristic ion pairs | 2-MMC m/z 178→145（CE 10eV） | |
Implementation recommendations
- Sample pretreatment requires the centrifugal speed to be controlled at ≥4000r/min to ensure extraction efficiency
- Standard solutions are recommended to be prepared and used immediately, and the shelf life is only 1 month
- Quantitative analysis requires a Grubbs test (n≥6) to control data quality
Technology evolution analysis
Compared with traditional GC-MS methods, the LC-MS technology used in this standard effectively solves the problem of thermal instability of cathinones, and the detection sensitivity of 3,4-methylenedioxy derivatives is increased by 10 times.
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