GB/T 39261-2020 in English

VALID

Nanotechnologies-Guidance on physico-chemical characterization of engineered nanoscale materials for toxicologic assessment

Issued on:2020-11-19
Implemented on:2021-06-01
File Format:PDF
Delivery:Via email within 5 business days

Price(USD)： $490.00
$476.00

Standard No:	GB/T 39261-2020
Document status:	VALID
Title in English:	Nanotechnologies-Guidance on physico-chemical characterization of engineered nanoscale materials for toxicologic assessment
Title in Chinese:	纳米技术纳米材料毒理学评价前理化性质表征指南
Language:	English
File Format:	Electronic (PDF)
Delivery:	Via email within 5 business days
Issued on:	2020-11-19
Implemented on:	2021-06-01
ICS Classification:	71.040.50-Physicochemical methods of analysis
Professional Classification:	GB-National Standard
Related Keywords:	toxicologic assessment introduction standard background physico-chemical characterization nanomaterial safety assessment system core characterization parameter framework parameter category key indicators examples engineered nanoscale materials
Related Topics:	nature toxicology Nano Physicochemical nanotechnology Nanochemistry Physical and chemical properties nanomaterials Physical and chemical standards nanotracer Toxicology Ecotoxicology Nanoscale Characteristic peaks of gold nanoparticles laboratory nanomaterials Nanomaterials and Technology Lightweight Nanocomposites Toxicology+ Evaluation Center Toxicology Methods for Characterizing Gold Nanomaterials Physical and chemical properties Toxicology Nanomaterial Definition Nanomaterial Definition Evaluate mental representations nanomaterials Inkjet Nanomaterials a nanometer nanoengineered materials nano mass spectrometry nanoagglomeration Toxicity of metal nanoparticles Nano size nanomaterials nano surface nano surface nanoengineered materials Toxicological analysis European Nanomaterials Nanomaterials for the first time Material Characterization Evaluation nanomaterials and me Nanomaterial Analysis nano-characterization and Nanomaterials and Products Nanodispersion Tellurium Nanomaterials Toxicological evaluation nanomaterials and nano Nanodispersion Toxicological evaluation Nanomaterials mtt Chemistry Materials Characterization Technology nanomaterial phase nanomaterial size Toxicological analysis Characterization of Gold Nanomaterials Characterizing Nanoparticles Structural Nanomaterials True Density Nanomaterials Functional Nano State-of-the-art technologies in materials chemistry current material technology Toxin physicochemical properties Future Nanomaterials Gold Nanomaterials Spectra Gold Nanomaterials + Spectroscopy Oriental Nanoscience and Nanotechnology nanocluster mass spectrometry Nanomaterials Engineering Nano material motor semi-nanometer material nano mass spectrometry "nanotechnology Materials Nanotechnology Research Frontiers of Nanomaterials Performance Characterization and Evaluation cobalt nanomaterials Frontier Characterization of Materials GBT39261 GB/T 39261-2020 Chemical Material Characterization Molecular Materials \| Nanomaterials \| Nanochemistry Nano\|Inorganic Nano\|Optoelectronic Nanomaterials\|Nanochemistry\|Nanotechnology\|Nanomaterials\|Nanostructures\|Catalysts\|Catalysis\|Catalytic Materials\|Fluid Mixing ND100 Nano Homogenizer Scientists in the field of nanomaterials Nanomaterial tracer Chemical biological toxicity evaluation UV measurement standard for nanometer copper oxide materials New techniques and methods in toxicology Nanomaterials and Technologies

《GB/T 39261-2020纳米技术纳米材料毒理学评价前理化性质表征指南》由TC279（全国纳米技术标准化技术委员会）归口，主管部门为中国科学院。

Introduction

Standard Background and Technological Evolution

GB/T39261-2020 is equivalent to the ISO/TR13014:2012 international standard, which indicates that my country's nanomaterial safety assessment system is in line with international standards. This standard systematically regulates the requirements for the characterization of physical and chemical properties before toxicological studies for engineering nanomaterials such as nanoparticles and carbon nanotubes.

Core Characterization Parameter Framework

Parameter Category	Key Indicators	Examples of Detection Methods
Physical Description	Particle Size Distribution/Agglomeration State/Specific Surface Area	Dynamic Light Scattering (DLS)/TEM Image Analysis
Chemical Composition	Elemental Composition/Crystal Structure/Surface Functional Groups	XPS/XRD/Raman Spectroscopy
Interface Properties	Zeta Potential/Dispersion Stability	Electrophoretic Light Scattering/UV-Visible Spectroscopy

Toxicology Correlation Analysis

Specific surface area is positively correlated with cellular uptake efficiency. For example, the inflammatory response intensity of 50nmtitanium dioxide is 3-5 times higher than that of 200nm particles. Surface charge regulates biodistribution by affecting protein corona formation. Cationicgold nanoparticles accumulate 40% more in the liver than anionic ones.

Implementation recommendations

Establish a three-stage characterization process of receiving-pre-exposure-post-exposure
Use ISO/IEC Guide 98-3 to evaluate measurement uncertainty
Give priority to the standardized test methods recommended by ISO/TC229

More samples: NB/T 47013.2-2015 GB 50021-2001(2009) JGJ 94-2008

Sample only — not a preview of GB/T 39261-2020

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