GB/T 41412-2022 in English
VALIDDetermination of isothiazolinone preservatives in toys—High performance liquid chromatography-tandem mass spectrometry
- Issued on:2022-04-15
- Implemented on:2022-04-15
- File Format:PDF
- Delivery:Via email within 1~3 business days
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《GB/T 41412-2022玩具中异噻唑啉酮类防腐剂的测定 高效液相色谱-串联质谱法》由TC253（全国玩具标准化技术委员会）归口，主管部门为中国轻工业联合会。
Introduction
Detection methods and technological innovation
This method breaks through the limitations of conventional detection and uses the combination of ultrasonic extractor and The application case of Shanghai Quality Inspection Institute shows that when analyzing soft PVC toys, the gradient elution strategy (see standard 5.4) is used to effectively separate the Cl⁻ interference peak. The addition of mixed internal standards can compensate for the BIT loss rate of 3.2%→0.8% caused by the centrifugation process. It is worth noting that the centrifugal operation at 6000r/min must ensure that the centrifugal radius is ≮10cm, otherwise it will cause density gradient disorder. Comparative tests show that the filter membrane transfer operation should be completed within 22 seconds after the centrifugation is completed. This method Traditional GC-MS Significance of difference Lowest limit of quantification 0.04mg/kg 0.1mg/kg 60% decrease Analysis cycle 8.5min/sample 22min/sample Time optimization by 61% Method recovery 85.7-106% 72-89% Precision improved by 18%↑ Implementation of application strategy
Quality assurance requirements
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