GB/T 15670.5-2017 in English

VALID

Toxicological test methods for pesticides registration. Part 5: Acute dermal toxicity test

Issued on:2017-07-12
Implemented on:2018-02-01
File Format:PDF
Delivery:Via email within 1~3 business days

Price(USD)： $160.00
$156.00

Standard No:	GB/T 15670.5-2017
Document status:	VALID
Title in English:	Toxicological test methods for pesticides registration. Part 5: Acute dermal toxicity test
Title in Chinese:	农药登记毒理学试验方法第5部分：急性经皮毒性试验
Language:	English
File Format:	Electronic (PDF)
Delivery:	Via email within 1~3 business days
Issued on:	2017-07-12
Implemented on:	2018-02-01
ICS Classification:	65.100-Pesticides and other agrochemicals
Chinese Classification:	B17-Pesticide management and application method
Professional Classification:	GB-National Standard
Related Keywords:	acute dermal toxicity test toxicological test methods toxicology test methods dermal toxicity test introduction gb/t acute dermal toxicity test standard requirements specific specifications new/changed content purpose
Related Topics:	toxicology toxicity Pesticide Registration Toxicology+ Toxicity test Pesticide Toxicity Test Acute Toxicity Analysis Toxicity verification Pesticide Registration Toxicology Test Unit t Toxicity Pesticide Registration Test Unit Pesticide Registration Test Unit Toxicity marker 14 Toxicology test acute toxicity in water Toxicology Test Unit Toxicology test Pesticide Toxicology Test Toxicity standard Pesticide Registration toxic pesticides Acute toxicity in water Acute Toxicity Test Pesticide Registration Toxicology Test Pesticide Toxicology Test Methods Pesticide Registration Toxicology Test Pesticide Registration Toxicology Test Unit Pesticide Test Registration Unit Toxicology test methods for pesticide registration Acute Toxicity Test Method Acute toxicity meter Acute toxicity 4 Toxicity test Acute Toxicity Toxicity Test Acute Toxicity Test Toxicity Drug Analysis Toxicity Drug Toxicology Toxicity Test Drugs Toxicity Test Toxicity Water Quality Acute Toxicity Test Water Toxicity Test Pesticide Registration Toxicology GBT15670.5 GBT15670.5-2017 local toxicity test GB 151933-2003 Acute toxicity test Pesticide 1065 toxicity National standard method for phytotoxicity testing Toxicology Experimental Methods and Techniques Which part of the Pharmacopoeia is the methodological validation in? Acute Toxicity Testing International Manual determination method of acute toxicity Pharmacopoeia Methodology Validation New techniques and methods in toxicology Xu Shuyun’s Pharmacological Experimental Methodology Test methods for acute and subacute inflammation Methodological Validation Pharmacopoeia Pharmacopoeia Part 4 Methodology Validation Pharmacological Experimental MethodologyXu Shuyun Pharmacopoeia Methodology Validation Pharmacological methodology validation

《GB/T 15670.5-2017农药登记毒理学试验方法第5部分：急性经皮毒性试验》由326（农业农村部）归口，主管部门为农业农村部。

Introduction

GB/T 15670.5-2017 Standard Overview

GB/T 15670.5-2017 "Toxicology Test Methods for Pesticide Registration Part 5: Acute Dermal Toxicity Test" is an indispensable and important standard in the pesticide registration process. This standard mainly stipulates the basic principles, methods and requirements of acute dermal toxicity tests, aiming to evaluate the health damage effects of pesticides on experimental animals and provide data support for subsequent toxicology studies.

Core Contents of Acute Dermal Toxicity Test

Standard Requirements	Specific Specifications	New/Changed Content
Purpose of the Test	To evaluate whether the pesticide can be absorbed through the skin and its toxic action mode	-
Selection of Experimental Animals	Rats, Rabbits, Guinea Pigs	New Principles for Selecting Animals of Sensitive Sexes
Dose Grouping	At least 3 dose groups	Modified to at least 3 dose groups, new limit test requirements
Exposure Time	24-hour continuous contact	Changed from 4 hours to 24 hours
Result processing	Calculation of LD50 and 95% confidence interval	Added requirements for dose-response relationship analysis

Test methods and steps

Test material preparation: Liquid test materials use stock solutions, and solid test materials need to be sieved through a 100-mesh sieve before moistening.

Experimental animal preparation: Animals need to adapt to the test environment for 3-5 days and be kept in single cages to avoid mutual interference.

Implementation recommendations

Precautions for practical application

Animal selection: Rats should be given priority according to experimental conditions. If other species are to be used, the reasons should be stated.
Dose setting: The dose range is determined in the preliminary test, and the dose gradient is designed using the Horn method or the probability unit method.
Toxicity assessment: The acute dermal toxicity level is determined by the LD50 value and the 95% confidence interval.
Data recording: Use a structured table to record the animal number, gender, dose, weight and observations.

More samples: DL/T 368-2010 DL/T 5154-2012 GB 50021-2001(2009)

Sample only — not a preview of GB/T 15670.5-2017

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