GB/T 21607-2022 in English

VALID

Chemicals—Test method of one-generation reproduction toxicity

Issued on:2022-07-11
Implemented on:2023-02-01
File Format:PDF
Delivery:Via email within 1~3 business days

Price(USD)： $150.00
$146.00

Standard No:	GB/T 21607-2022
Document status:	VALID
Title in English:	Chemicals—Test method of one-generation reproduction toxicity
Title in Chinese:	化学品一代繁殖毒性试验方法
Language:	English
File Format:	Electronic (PDF)
Delivery:	Via email within 1~3 business days
Issued on:	2022-07-11
Implemented on:	2023-02-01
Superseding:	GB/T 21607-2008 Test method of one-generation reproduction toxicity for chemicals
ICS Classification:	13.300-Protection against dangerous goods
Chinese Classification:	A80-Marking, packaging, transport and storage in general
Professional Classification:	GB-National Standard
Related Keywords:	one-generation reproduction toxicity introduction analysis control group chemicals test method technical solutions toxic measurement management gestation error precise control blank control
Related Topics:	reproduce toxicity Chemical Standards toxic reaction chemicals in english toxic reaction Toxicity test generation toxic method Virus passage method toxic chemicals in water reaction toxicity t Toxicity consistency chemistry Chemical Standards colonization in medicine method of vegetative reproduction of plants Toxicity standard breeding animals Chemical Toxicity Test breeding system parthenogenetic animals asexually reproducing animals same-sex reproduction self reproduction toxic sample parthenogenetic organisms Phase IV Toxicity Reproductive Toxicity Parthenogenesis Parthenogenesis Toxicity test kawk, drugs parental GBT21607 GB/T 21607-2008 GB/T 21607-2022 Chemicals local toxicity test Toxicology Experimental Methods and Techniques The latest national standard for chemical generation reproductive toxicity testing Outbred breeding method Methodological validation representative chart Sanguispora propagation method Areca palm propagation method Test methods for flammability of chemicals

《GB/T 21607-2022化学品一代繁殖毒性试验方法》由TC251（全国危险化学品管理标准化技术委员会）归口，TC251SC1（全国危险化学品管理标准化技术委员会化学品毒性检测分会）执行，主管部门为国家标准化管理委员会。

Introduction

Analysis of the key changes in the standard

Compared with the 2008 version, the new version of GB/T21607-2022 has made major technical adjustments in three areas:

Technical dimensions	2008 version regulations	2022 version updates
Selection of experimental animals	No clear adaptation period requirements	At least 5 days of adaptation period is required, with special emphasis on the weight requirements of rats/mice (±20%)
Poisoning period	8 weeks for males	Specify that rats should be ≥10 weeks, and mice should be maintained for 8 weeks (complete sperm cycle)
Control settings	Blank control only	New requirements for excipient control and diet ratio

Laboratory Animal Management Standards

When selecting SPF rats for experimental animals, attention should be paid to the following:

According to the 2023 laboratory validation data, the reproductive index of Wistar rats increased by 7.2% after the new standard operation, and the average weight difference between pregnant groups decreased from 12.5% to 4.3%

Implementation optimization suggestions

Operational links	Risk control points	Technical solutions
Toxic measurement management	Gestation error	Precise control using electronic gavage system
Cub tracking	Individual confusion	Implantable RFID chip identification

Standard diagram of data analysis

Key evaluation formula:

Conception rate = (number of conceptions/number of mated females) × 100%

When the conception rate of the experimental group is significantly lower than that of the control group (p＜0.05), in-depth analysis of reproductive toxicology should be initiated

More samples: DL/T 368-2010 GB 50021-2001(2009) JC/T 2453-2018

Sample only — not a preview of GB/T 21607-2022

Loading PDF document...

Error loading PDF. Please make sure the file is valid and try again.

We also recommend

GB/T 14492-2008 in English

Unreusable steel drum of calcium carbide for packing
2008-08-04
GB/T 44640-2024 in English

Chemicals—Xenopus eleutheroembryonic thyroid assay
2024-09-29
GB/T 7694-2008 in English

The rule of nomenclature for dangerous goods
2008-08-04
GB/T 15956-2008 in English

Calcium carbide steel drum for repeated use
2008-08-04
GB/Z 24783-2009 in English

Guidance on socio-economic analysis of chemicals-r
2009-12-15
GB/T 24774-2009 in English

Classification and hazard pictograms for chemicals—General specification
2009-12-15
GB/T 21772-2025 in English

Chemicals—Test method of mammalian bone marrow chromosome aberration
2025-10-05