GB/T 35948-2018 in English

Interpretation of the National Standard of the People's Republic of China GB/T 35948—2018

Background and Significance of the Standard

This standard was formulated to meet the detection needs of banned substances in cosmetics and to standardize the application of high performance liquid chromatography (HPLC) in the determination of 4-hydroxybenzoic acid ester compounds. These compounds include:

Scope of application and limit value

This standard is applicable to the determination of the above 7 substances in creams, emulsions, gels, water, powders, wax-based cosmetics, etc. The detection limit and quantification limit of the method are both 2~6 mg/kg to ensure the validity and reliability of the test results.

Analysis methods and technical details

Reagents and instruments

The main instruments used include: High performance liquid chromatograph (with diode array detector), Analytical balance, etc. The preparation of standard solution requires the use of first-grade pure water and chromatographic reagents to ensure the accuracy of the data.

Sample processing steps

Determination steps and standard curve

The HPLC reference conditions include: core-shell C18 column, gradient elution and specific wavelength detection. The accuracy of the sample determination results is ensured by drawing a standard curve of the mixed standard working solution.

Result calculation and precision analysis

Content calculation formula: $$ X_{i}=\frac{(c_{i}-c_{0})\times V}{m}\times f $$

Implementation suggestions