GB/T 37544-2019 in English
VALIDDetermination of 6 kinds of phenolic antibacterial agent including o-cymen-5-ol in cosmetics—High performance liquid chromatography
- Issued on:2019-06-04
- Implemented on:2020-01-01
- File Format:PDF
- Delivery:Via email within 1~3 business days
$156.00
《GB/T 37544-2019化妆品中邻伞花烃-5-醇等6种酚类抗菌剂的测定 高效液相色谱法》由TC257（全国香料香精化妆品标准化技术委员会）归口，TC257SC2（全国香料香精化妆品标准化技术委员会化妆品分会）执行，主管部门为中国轻工业联合会。
Introduction
1. Background and significance of standard formulation
GB/T 37544—2019 was formulated based on the requirements of my country's "Technical Specifications for Safety of Cosmetics (2015 Edition)", which clearly states that phenol, para-chloro-meta-cresol and other substances are prohibited ingredients. Since these substances may exist as impurities, their content in cosmetics needs to be tested to ensure safety. This standard fills the gap in domestic testing methods for these specific antimicrobial agents and has important industry guidance significance.
2. Standard framework and core content
| Chapter number | Chapter content | Key analysis |
|---|---|---|
| 1 | Scope | The applicable objects and testing methods of the standard are clarified. |
| 2 | Normative references | Key standards such as GB/T6682 are cited to ensure the quality requirements of experimental water. |
| 3 | Principle | Qualitative and quantitative analysis is performed using high performance liquid chromatography and mass spectrometry (HPLC-MS/MS). |
3. Implementation suggestions and precautions
3.1 Laboratory conditions
- Instruments:High-end equipment such as high performance liquid chromatography (HPLC) and mass spectrometry are required.
- Reagent materials:Including special chemical reagents such as acetonitrile and formic acid, the purity and storage conditions must be ensured.
- Staff training:Operators must undergo professional training and be familiar with the operation and maintenance of HPLC and mass spectrometers.
3.2 Sample processing flow
According to different types of cosmetics (aqueous, emulsion, etc.), corresponding extraction methods are used. For example:
- For aqueous and emulsion types, the sampling volume is 0.2g, and vortex oscillation and ultrasonic extraction are performed after adding acetonitrile aqueous solution.
- For wax-based cosmetics, they must be dissolved in tetrahydrofuran before subsequent processing.
3.3 Result calculation and quality control
Calculate according to the formula w = [(ρ - ρ₀) × V × 1000] / (m × 1000) to ensure the accuracy and precision of the data. The recovery rate should be in the range of 80%-110%, and the relative standard deviation should be less than 10%.
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