GB/T 39630-2020 in English
VALIDColloidal solution of silver nanoparticles
- Issued on:2020-12-14
- Implemented on:2021-07-01
- File Format:PDF
- Delivery:Via email within 1~3 business days
$156.00
《GB/T 39630-2020纳米银胶体溶液》由TC279(全国纳米技术标准化技术委员会)归口,TC279SC1(全国纳米技术标准化技术委员会纳米材料分会)执行,主管部门为中国科学院。
Introduction
Analysis of the core content of the standard
GB/T39630-2020 has formulated comprehensive technical specifications for nanosilver colloidal solution, which mainly includes three technical systems:
| Technical dimensions | Key indicators | Test methods |
|---|---|---|
| Physical and chemical properties | pH value (1-100), elemental silver ratio (≥50%), average particle size (≤10nm) | X-ray photoelectron spectroscopy (XPS), dynamic light scattering (DLS) |
| Safety performance | Lead (<2mg/L), arsenic (<1mg/L), acute oral toxicity (LD50>5000mg/kg) | ICP-MS, animal experiments |
| Antibacterial efficacy | Escherichia coli/Staphylococcus aureus antibacterial rate (≥90%), stability (≥6 months) | HG/T4317 antibacterial test |
In-depth interpretation of technical indicators
Particle size control requirements
The standard stipulates that the average particle size is ≤10nm, which is determined by small-angle X-ray scattering method.
- 1-5nm: has the highest specific surface area and active silver ion release rate
- 5-20nm: balance stability and antibacterial effect
- >50nm: may reduce bioavailability
Silver valence state analysis technology
When using XPS to analyze the proportion of elemental silver, please note:
- Sample preparation needs to be vacuum dried to constant weight
- The type and concentration of anions and cations need to be recorded
- Ag3d5/2 binding energy of 368.2eV is the characteristic peak of elemental silver
Standard implementation recommendations
Application in medical fields
When used in wound dressings, it is recommended to:
- Select a solution with a particle size of 3-8nm and an absolute value of Zeta potential > 30mV
- Control the total silver concentration at 10-50mg/L
- Add antibacterial test for Pseudomonas aeruginosa
Adaptation for daily chemical products
Note that when used in antibacterial hand sanitizers:
- The pH value needs to be adjusted to 5.5-7.0 for skin compatibility
- It is necessary to pass multiple skin irritation tests
- It is recommended to add 0.1% disodium EDTA to improve stability
Analysis of standard evolution
Compared with the international standard ISO/TS 80004-6:2021, GB/T39630-2020 has the following characteristics:
- Added quantitative requirements for the proportion of elemental silver
- Refine the limit indicators for heavy metal impurities
- Specify the minimum antibacterial rate threshold
- Introduce accelerated stability test methods

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