GB/T 43273-2023 in English
VALIDDetermination of freeze/thaw stability for pesticides
- Issued on:2023-11-27
- Implemented on:2024-06-01
- File Format:PDF
- Delivery:Via email within 1~3 business days
$97.00
《GB/T 43273-2023农药冻融稳定性测定方法》由TC133（全国农药标准化技术委员会）归口，主管部门为农业农村部。
Introduction
1. Background and significance of standard formulation
The formulation of the freeze-thaw stability test method of pesticides is to ensure the stability and effectiveness of pesticides under different environmental conditions. With the diversification of pesticide formulations, especially the emergence of new formulations such as microcapsule suspensions and microcapsule suspension-suspension concentrates, higher requirements are put forward for freeze-thaw stability testing.
2. Comparative analysis of standard frameworks
| Dimensions | GB/T 43273-2023 | Comparison with old standards |
|---|---|---|
| Scope of application | Microcapsule suspension, microcapsule suspension-suspension, etc. | Only applicable to traditional dosage forms |
| Test items | Mass fraction of free active ingredients, acidity (alkalinity), pH value, pourability, etc. | Basic physical and chemical properties test |
| Temperature control | (-10±2)℃ and (20±2)℃ | (-15±3)℃ and (20±2)℃ |
3. Interpretation of core test methods
Freeze-thaw stability tester is a key instrument for determining the freeze-thaw stability of pesticides. Its temperature control accuracy directly affects the test results. According to the standard requirements, keep it at (-10±2)℃ for 18 hours, then keep it at (20±2)℃ for 6 hours, and repeat this for 4 cycles.
Actual application case: microcapsule suspension test
A pesticide company used the GB/T 43273-2023 standard to test the freeze-thaw stability of microcapsule suspensions. The results showed that after 4 freeze-thaw cycles, the mass fraction of free active ingredients remained above 98%, indicating that the product has good freeze-thaw stability.
4. Implementation Suggestions
- Strictly control the number of freeze-thaw cycles and temperature in accordance with standard requirements
- Select appropriate instruments and equipment (such as constant temperature box) to ensure test accuracy
- Determine the sampling volume and test items according to the characteristics of the dosage form
- Regularly calibrate the instrument to ensure the accuracy of the measurement data
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