GB/T 44366-2024 in English
VALIDDetermination of restricted lauryl alcohol polyether-9 in cosmetics—Liquid chromatography tandem mass spectrometry
- Issued on:2024-08-23
- Implemented on:2025-03-01
- File Format:PDF
- Delivery:Via email within 1~3 business days
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《GB/T 44366-2024化妆品中限用组分月桂醇聚醚-9的测定 液相色谱-串联质谱法》由TC257（全国香料香精化妆品标准化技术委员会）归口，TC257SC2（全国香料香精化妆品标准化技术委员会化妆品分会）执行，主管部门为中国轻工业联合会。
Introduction
Interpretation of the detection method of the restricted ingredient laureth-9 in cosmetics
| Detection method | Principle | Scope of application | Advantages | Disadvantages |
|---|---|---|---|---|
| Liquid chromatography-tandem mass spectrometry | Separation + high-sensitivity detection | Aqueous agents, creams, lotions, etc. | High sensitivity and good selectivity | Complicated operation and expensive equipment |
| Other chromatography methods | High performance liquid chromatography | Aqueous samples | High separation efficiency | Low sensitivity |
Standard formulation background and technology evolution analysis
Technical principles and application cases
Liquid chromatography-tandem mass spectrometry (LC-MS/MS) is an efficient separation and detection technology, especially suitable for trace analysis in complex matrices. This method uses a C18 chromatographic column to separate the target compounds, achieves efficient separation through gradient elution, and uses an electrospray ion source and multiple reaction monitoring mode (MRM) for high-sensitivity detection.
In practical applications, this method has been successfully used to detect a variety of cosmetic samples, including water-based, cream-based and lotion-based products. The accuracy and reliability of the results are ensured by drawing a standard curve and quantifying by external standard method.
Implementation recommendations
- Equipment selection and calibration:It is recommended to use a triple quadrupole mass spectrometer with stable performance and calibrate the instrument parameters regularly to ensure detection accuracy.
- Reagent and consumables management:It is recommended to use high-purity chromatographic grade reagents and filter with a pore size of 0.22 μm to avoid interference from impurities.
- Sample pretreatment optimization:For different types of cosmetic samples (such as creams and lotions), the extraction conditions (such as oscillation time and ultrasonic time) can be appropriately adjusted to improve the recovery rate.
- Data quality control:It is recommended to establish a complete quality control system, including blank tests, repeated measurements and standard curve verification, to ensure the reliability and compliance of the data.
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