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WS/T 381-2021 in English

WS/T 381-2021 in English

VALID

Diagnosis standard of cysticercosis

  • Issued on:2021-11-23
  • Implemented on:2022-05-01
  • File Format:PDF
  • Delivery:Via email within 5 business days
Price(USD): $500.00
$485.00
Standard No: WS/T 381-2021
Document status: VALID
Title in English: Diagnosis standard of cysticercosis
Title in Chinese: 囊尾蚴病诊断标准
Language: English
File Format: Electronic (PDF)
Delivery: Via email within 5 business days
Issued on: 2021-11-23
Implemented on: 2022-05-01
Superseding: WS 381-2012 Diagnosis of cysticercosis
Professional Classification: WS-Hygiene
Related Keywords: diagnosis standard
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differential diagnosis
standard revision dimensions
Related Topics: semi-quantitative diagnosis
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Introduction

Core changes in the standard revision

Dimensions 2012 version 2021 version
Detection methods Only etiology + immunology Added Nucleic acid detection (Appendix D.3)
Imaging diagnosis Basic CT description Added MRI staging features + typical images (Appendix E)
Clinical classification Type 3 cases Five subcategories (subcutaneous/brain/eye/other/mixed)

Key diagnostic techniques

1. Etiological testing

Surgical removal of nodules requires squeezing test (detection rate 82%) or cysticercosis hatching test (live identification), and pathological sections require observation of the scolex sucker structure (see Figure E.1 for details).

2. Immunological testing

ELISA method for detection of IgG/IgG4/IgM antibodies, with a critical value of S/N ≥ 2.1. IgG4 can be used for efficacy evaluation (negative conversion rate 75% 6 months after treatment).

3. Nucleic acid detection

PCR amplification was performed using ITS gene primers (BD1/BD2), and a 1000bp band was visible in positive samples (sensitivity increased by 30% compared with traditional methods).


Imaging diagnosis stages

Characteristics of the four stages of brain parenchymal type:

  • Survival stage: CT shows 5-15mm low-density cysts with eccentric head ganglion (Figure E.1)
  • Degeneration stage: MRI-T2WI shows thick-walled ring enhancement + surrounding edema (Figure E.7)
  • Calcification stage: CT high-density nodules (2-8mm) without enhancement

Implementation recommendations

1. Screening in epidemic areas: Serum antibody testing is given priority for epilepsy patients (the positive rate can reach 68%)
2. Image selection: MRI+FLAIR sequence is recommended for brain type cases (the detection rate of head ganglion is increased by 40%)
3. Differential diagnosis: Subcutaneous nodules need to be distinguished from sparganosis (migratory) and lipoma (scolex)

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