GB/T 28599-2020 in English

VALID

Determination of phthalate esters in cosmetics

Issued on:2020-09-29
Implemented on:2021-01-01
File Format:PDF
Delivery:Via email within 1~3 business days

Price(USD)： $250.00
$243.00

Standard No:	GB/T 28599-2020
Document status:	VALID
Title in English:	Determination of phthalate esters in cosmetics
Title in Chinese:	化妆品中邻苯二甲酸酯类物质的测定
Language:	English
File Format:	Electronic (PDF)
Delivery:	Via email within 1~3 business days
Issued on:	2020-09-29
Implemented on:	2021-01-01
Superseding:	GB/T 28599-2012 Determination of phthalate esters in cosmetics
ICS Classification:	71.100.70-Cosmetics. Toiletries
Chinese Classification:	Y42-Cosmetics
Professional Classification:	GB-National Standard
Related Keywords:	methods gc/ms method matrix application hplc method solid phase extraction column polish hplc method excludes phenyl-methylpolysiloxane capillary column temperature program
Related Topics:	cosmetic dicarboxylate Cosmetic Dimethyl Sulfate National Cosmetics Classification of formic acid Phthalate test iso phthalic acid Phthalates en Phthalates double Benzoic acid detection in water phthalate alcohol Quality of Terephthalic Acid Indicators for phthalates gb/t28599 Rapid detection method for phthalates GB/T28599-2012 Fertilizer Phthalates Chroma of Phthalates Soil Phthalates Test methods for industrial phthalates acidity Cosmetic Standards Determination of Benzene Series in Water Quality How to Detect Phthalates Phthalic acid diesters Phthalates Soil Phthalates Testing Phthalates Infrared In the determination of benzene, toluene, ethylene o-xylene Air Phthalates Determination Phthalates + Infrared Zirconium Bromophthalate Phthalates Infrared Esters Phthalates Detection Phthalate Rapid Test Soil Phthalates Determination gb28599 Phthalates adjacent Phthalates Determination Dimethyl sulfate in cosmetics Phthalates Residues of Benzophenones and Parabens in Exported Aquatic Products Determination of Dimethyl Sulfate and Diethyl Sulfate in Cosmetics by Gas Chromatography-Mass Spectrometry Infrared Spectrum of Phthalates Phthalates and Detection Dimethyl Sulfate and Diethyl Sulfate in Cosmetics Method for the detection of phthalic acid diesters Phthalate Ash Phthalate Ash Rubber Products Phthalates Phthalate Preparation Esters 16 kinds of phthalic acids in food methylated toluene Neighborhood adjacent lead phthalate Benzoic acid in meat products Determination of benzene series in water quality Benzene series in the determination of water quality benzene series How to Detect Xylene in Water Gas Determination of Phthalates Phthalate heating Benzoic acid Detection of phthalic acid in water class National Cosmetics Benzophenones Phthalates Measuring Phthalates in Water Portable Gas Determination of Phthalates Phthalic acid photometry What is phthalic acid How to measure phthalic acid How to Detect Phthalates Determination method of xylene in water solid cosmetics Phthalates triphenyl in chemicals How to measure xylene in water Phthalic acid and ferric chloride Phthalate Cosmetics Phthalates Detection Cosmetic Phthalates Diesters dicarboxylic acid Phthalate testing disulfone phthalate dicarboxylate GBT28599 GB/T 28599-2012 GB/T 28599-2020 Infrared spectrum of phthalates in cosmetics Liquid quality detection method of phthalic acid in benzoic acid The main uses of xylene in experiments vdi4301 Chinese version phthalate Chemical properties of xylene Description of the physical and chemical properties of xylene Phthalate transport in plants Mass spectrometry analysis of methyl benzoate Disinfectants Determination of Phthalates Methyl benzoate pesticides Dimethyl terephthalate product quality Phthalate standard samples have certificates Determination method for residual chlorobenzenes in polycarbonate Toluene content in cosmetics Determination of water quality xylene What are the liquid quality methods for determining phthalates? Chemical Class A Library Design Determination method of diphenyl phosphate Safety Technical Specifications for Cosmetics Determination of Benzene What are the detection methods for benzene in cosmetics? Detection method for terephthalyl compounds Method for determination of benzene in cosmetic formulations Phthalic acid product quality Dimethyl sulfate quality Phthalate detection Determination method of toluene in water quality Terephthalic acid chemicals Testing methods for ester substances Determination of xylene in water gbt28599-2020dz

《GB/T 28599-2020化妆品中邻苯二甲酸酯类物质的测定》由TC374（全国质量监管重点产品检验方法标准化技术委员会）归口，主管部门为国家标准化管理委员会。

Introduction

Core changes in the standard update

Revision dimensions	2012 version	2020 version
Number of test substances	18-22	Unified to 24
Scope of matrix application	HPLC method is applicable to nail polish	HPLC method excludes nail polish
Limit of detection (LOD)	Large differences between methods	GC/MS method is unified to 1.0mg/kg

Comparison of technical methods

Method 1: GC/MS (arbitration method)

Innovation: Silica/PSA solid phase extraction column is used for purification, and SIM mode scanning uses the quantitative ion abundance ratio as the qualitative basis

Gas chromatography-mass spectrometryParameters:

Chromatographic column: 5% phenyl-methylpolysiloxane capillary column
Temperature program: 60℃(1min)→220℃(4min)→290℃(5min)
Characteristic ions: DMP(163), DEHP(149), etc.

Method 2: HPLC

Optimization: Added gradient elution program (methanol/acetonitrile-water system), DAD detector 240nm wavelength analysis

High performance liquid chromatography Key conditions:

Chromatographic column: XDB C8 (250mm×4.6mm,5μm)
Flow rate: 1.0mL/min
Column temperature: 40℃

Third method: GC

Application scenario: Routine analysis of FID detector, attention should be paid to the interference of nail polish matrix

Difference in heating program:

220℃ for 4.5min (0.5min longer than GC/MS)
Final heating rate 15℃/min (20℃/min for GC/MS)

Suggestions for the implementation of the standard

Main points for matrix pretreatment

Aqueous agents: Direct extraction with n-hexane to avoid contamination of plastic containers
Cream: Methanol ultrasonication requires sodium chloride demulsification
Solid: Sea sand is recommended for auxiliary grinding of lipstick samples

Quality control requirements

Blank tests must be conducted simultaneously
Relative deviation of parallel samples ≤15%
Positive results must be repeated by GC/MS

Technology evolution analysis

The revision of this standard reflects three major trends: ①Detection sensitivity improved (GC/MS quantitative limit reduced from 5.0mg/kg to 2.5mg/kg); ② The universality of the method was enhanced (full coverage of 24 substances); ③ Green detection concept (reducing the amount of organic solvents, solid phase extraction instead of liquid-liquid extraction).

More samples: JJG 21-2008 YD/T 3934-2021 DL/T 368-2010

Sample only — not a preview of GB/T 28599-2020

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