GB/T 35954-2018 in English
VALIDDetermination of 10 whitening and freckle-removing components in cosmetics—High performance liquid chromatography
- Issued on:2018-02-06
- Implemented on:2018-09-01
- File Format:PDF
- Delivery:Via email within 1~3 business days
$136.00
《GB/T 35954-2018化妆品中10种美白祛斑剂的测定 高效液相色谱法》由TC257（全国香料香精化妆品标准化技术委员会）归口，TC257SC2（全国香料香精化妆品标准化技术委员会化妆品分会）执行，主管部门为中国轻工业联合会。
Introduction
High Performance Liquid Chromatography Determination Method for 10 Whitening and Anti-freckle Agents in Cosmetics
This standard specifies the high performance liquid chromatography determination method for 10 whitening and anti-freckle agents such as magnesium ascorbyl phosphate and ascorbyl glucoside in cosmetics. It is applicable to various types of cosmetics such as water-based, emulsions, creams, etc.
Comparison of standard frameworks
| Serial number | Compound name | Detection limit (%) | Quantification limit (%) | Precautions |
|---|---|---|---|---|
| 1 | Magnesium ascorbyl phosphate | 0.003 | 0.008 5 | Pay attention to the dispersion effect in sample processing |
| 2 | Ascorbyl glucoside | 0.002 5 | 0.007 5 | Applicable to water-based samples |
| 3 | β-Arbutin | 0.016 7 | 0.025 | Extraction efficiency must be ensured |
Detailed description of the determination steps
Sample treatment:Water-based and emulsion samples need to be extracted by ultrasonic for 20 minutes, and the supernatant should be filtered after centrifugation.
Instrument:High performance liquid chromatography with diode array detector (DAD), the mobile phase is a gradient combination of potassium dihydrogen phosphate solution and methanol.
Implementation suggestions
1. Sample collection: Ensure that the sample volume is accurate. It is recommended to use an analytical balance accurate to 0.0001g.
2. Reagent preparation: The standard stock solution needs to be stored at -18℃ and is valid for one month.
3. Quality control: Regularly calibrate the instrument to ensure that the column temperature is stable at 25°C.
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