GB/T 37640-2019 in English

GB/T 37640—2019 Standard Interpretation

Background and Significance: This standard specifies the detection methods for six banned aldehydes and ketones (chloroacetaldehyde, crotonaldehyde, etc.) in cosmetics. These substances may pose risks to human health, so it is necessary to ensure that their content in cosmetics is below the safety threshold or completely absent.

Comparison of Standard Frameworks

Instrument and Reagent Specifications

Instrument and Equipment:High Performance Liquid Chromatography (with Diode Array Detector) is the core tool, ensuring high sensitivity and high resolution separation. Auxiliary equipment such as analytical balance and vortex oscillator provide precise sample processing capabilities.

Reagent Requirements:All reagents are analytically pure, and primary water is used in experiments to ensure the reliability of data. There are strict step requirements for the preparation of buffer solutions and derivatization agents.

Experimental Steps Analysis

Sample Processing:Different pretreatment methods are used according to the type of cosmetics (such as water, creams, etc.) to ensure the effective extraction of target substances. Pay special attention to the processing flow of wax-based samples, including n-hexane dispersion and subsequent separation operations.

Standard curve drawing:By preparing standard solutions of different concentrations and performing HPLC determination, a linear regression model is established for quantitative analysis.

Result calculation and precision

The content of the measured component in the sample is calculated using a formula, considering the influence of the blank test to ensure data accuracy. The data of recovery rate and relative standard deviation show that the method has good reliability and repeatability.

Implementation suggestions

Laboratory:Equipped with a complete HPLC system and pretreatment equipment, and a standardized operating procedure is established.

Staff training: Regularly conduct standard operation training to ensure that testers are familiar with sample handling and data interpretation.

Quality control: Strictly carry out blank tests and repeatability tests in accordance with standard requirements to ensure the accuracy of the results.