GB/T 39183-2020 in English
VALIDDetermination of the migration quantity of nitrosamines in consumer products—Gas chromatography-tandem mass spectrometry
- Issued on:2020-10-21
- Implemented on:2020-10-21
- File Format:PDF
- Delivery:Via email within 1~3 business days
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《GB/T 39183-2020消费品中亚硝胺迁移量的测定 气相色谱-串联质谱法》由TC508（全国消费品安全标准化技术委员会）归口，主管部门为国家标准化管理委员会。
Introduction
Analysis of the core content of the standard
This standard establishes a detection method for the migration of 15 N-nitrosamines and their precursors by gas chromatography-triple quadrupole mass spectrometry for elastomeric materials (such as latex, rubber, PVC, etc.) that can be contacted orally in consumer products. The quantitative limit of the method reaches 0.025-0.125μg/kg, which meets the international consumer product safety testing requirements.
Technical innovation
Artificial saliva simulation migration system: The migration experiment is carried out at 40℃ using simulated saliva with a pH of 9.0 (containing NaHCO₃, NaCl and other components) to truly simulate the oral contact environment. Through experimental verification, the system uses a 240-minute migration time for long-term contact products such as baby pacifiers and a 60-minute migration time for short-term contact products such as balloons.
Comparison of key detection processes
| Steps | N-nitrosamine detection | Detection of nitrosatable substances |
|---|---|---|
| Pretreatment | Direct alkalization treatment (solution A) | Nitrosation reaction under acidic conditions (solution B) |
| Solid phase extraction | PS-DVB solid phase extraction column cleanup, ethyl acetate elution | |
| Detection mode | MRM mode, electron impact ionization (70eV) | |
Key points for implementation
- Light-proof operation: The whole process needs to be protected from light, and the standard solution needs to be stored frozen at -18℃
- Quality control: The blank test value should be lower than the method quantitative limit, and the recovery rate should be controlled at 55-110%
- Instrument calibration: It is recommended to regularly calibrate the collision energy parameters of the triple quadrupole mass spectrometer
Background of standard evolution
This standard fills the gap in the detection method of nitrosamine migration in consumer products in my country. The technical route refers to EU EN 12868:2017, but innovatively:
- Indirect determination scheme for nitrosatable substances has been added
- The solid phase extraction process has been optimized, and the recovery rate has been increased by 15%
- Expanded detection of substances to 15 nitrosamine compounds
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