GB/T 40894-2021 in English
VALIDDetermination of prohibited substances thiamazole in cosmetics—High performance liquid chromatography
- Issued on:2021-11-26
- Implemented on:2022-06-01
- File Format:PDF
- Delivery:Via email within 1~3 business days
$175.00
《GB/T 40894-2021化妆品中禁用物质甲巯咪唑的测定 高效液相色谱法》由TC257（全国香料香精化妆品标准化技术委员会）归口，TC257SC2（全国香料香精化妆品标准化技术委员会化妆品分会）执行，主管部门为中国轻工业联合会。
Introduction
Analysis of the core content of the standard
This standard systematically specifies the detection method for the determination of methimazole in cosmetics by high performance liquid chromatography. The main technical features include:
| Technical parameters | General conditions | Mass spectrometry confirmation conditions |
|---|---|---|
| Chromatographic column | C18(250×4.6mm,5μm) | C18(150×2.1mm,3μm) |
| Mobile phase | Water:methanol=9:1 | Methanol:0.1%formic acid=5:95 |
| Detection limit | 0.33mg/kg | |
Method principle and technological innovation
Dual-dimensional qualitative analysis was performed using a diode array detector:
- Retention time matching (main peak 4.5min)
- UV spectrum comparison (characteristic absorption 253nm)
The innovative introduction of the secondary mass spectrometry confirmation process ensures detection accuracy through two pairs of characteristic ion fragments of m/z115.1→88.1 and 115.1→56.1.
Key points of standard implementation
Precautions for sample pretreatment
- The extraction solvent must be chromatographic grade methanol
- Centrifugal speed ≥10000r/min
- The filter membrane should be made of PTFE (0.22μm)
Quality control requirements
Method validation shows:
- Recovery range 91.5%-117%
- Precision RSD≤10%
Inspiration from industry development
This standard fills the gap in the detection method of methimazole in cosmetics in my country. Its technical characteristics reflect:
- The technical evolution from single chromatography detection to chromatography-mass spectrometry
- The development trend of the control of banned substances from qualitative detection to trace quantification
- The coordinated demand for standardization of detection methods and risk assessment
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