SN/T 5309-2021 in English

VALID

Food contact materials Polymers Determination of nonylphenol and octylphenol in food simulants Liquid chromatography-mass spectrometry method

Issued on:2021-11-22
Implemented on:2022-06-01
File Format:PDF
Delivery:Via email within 1~3 business days

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Standard No:	SN/T 5309-2021
Document status:	VALID
Title in English:	Food contact materials Polymers Determination of nonylphenol and octylphenol in food simulants Liquid chromatography-mass spectrometry method
Title in Chinese:	食品接触材料高分子材料食品模拟物中壬基酚和辛基酚的测定液相色谱―串联质谱法
Language:	English
File Format:	Electronic (PDF)
Delivery:	Via email within 1~3 business days
Issued on:	2021-11-22
Implemented on:	2022-06-01
Professional Classification:	SN-Import&Export Inspection
Related Keywords:	food simulants liquid chromatography-mass spectrometry method introduction analysis food simulants different food simulants food contact materials polymers determination 104-40-5 isooctane simulants
Related Topics:	mass spec product ion food contact material phenol tandem mass spectrometry MS Precursor Ion MS Precursor Ion Mass Spectrometry Conditions Mass spec mode Mass Spectrometry Conditions food contact material pentachlorophenol Mass Spec + Precursor Ion Octylphenol Food contact material + pentachlorophenol Precursor ions for mass spectrometry Phenol mass spectrum Organic matter in polymer materials MS ionization liquid chromatography tandem mass spectrometry liquid chromatography tandem mass spectrometry Polymer Chromatography Mass Spectrometry Polyphenols liquid chromatography tandem mass spectrometry Liquid Chromatography-Tandem Mass Spectrometry Liquid Chromatography-Tandem Mass Spectrometry mass spectrometric product ions food contact material Chromatographic material Phenol mother Chromatography simulation base spectrum Mass Spectrum Simulated Peaks How to Simulate Mass Spectrometry Chromatography Simulation Polymer Chromatography water based contact Chromatographic polymer materials Phenol mass spectrum Food Grade Contact Materials high-end ingredients food ingredients Food contact material bisphenol A Liquid Chromatography - Tandem Mass Spectrometry Liquid Chromatography - Tandem Mass Spectrometry liquid chromatography tandem mass spectrometry Phenolic Total phenols in food Phenol+ as5309 Spectrum phenol liquid phase in series Liquid Chromatography Tandem Chromatography simulation food simulants Determination of total phenols in food simulated mass peaks Phenol liquid phase Mass spectrum phenol Mass spec mode Phenolic food simulants food simulation liquid chromatography-tandem mass spectrometry liquid chromatography tandem mass spectrometry liquid chromatography mass spectrometry tandem Mass Spectrum of Phenol Chromatographic material Determination of total phenols in food Mass Spectrometry Food Packaging Materials Total Food Phenols Mass Spectrometry Food Contact Materials Food Contact Material Parameters Mass spectrum baseline is too high mass spectrum How to deal with high mass spectrum baseline Determination of total phenols in food Determination of nonylphenol by gas chromatography new food contact materials Contact angle measurement of carbon-based materials food materials

Introduction

Analysis of the core content of the standard

This standard adopts liquid chromatography-tandem mass spectrometry to determine 4 kinds of alkylphenols in food simulants. The technical points include:

0.001

Test substance	CAS number	Detection limit (mg/kg)	Quantification limit (mg/kg)
4-Nonylphenol	104-40-5	0.001	0.005
Nonylphenol mixture
4-Octylphenol	140-66-9	0.0005	0.001
Octylphenol	1806-26-4	0.0005	0.001

Key Technical Parameters

Chromatographic Conditions

Chromatographic Column: class=instrument>C18 column(2.1×130mm,2.7μm)
Mobile phase: methanol-water (90+10)
Flow rate: 0.2mL/min
Injection volume: 5μL

Mass spectrometry conditions

Ion source: electrospray ionization (ESI negative mode)
Scan mode: multiple reaction monitoring (MRM)
Nebulizer gas pressure: 20psi
Collision energy: 12-40eV (adjusted according to the compound)

Key points for standard implementation

Differences in sample pretreatment

Different treatments are used for different food simulants:

Water-based/acidic/alcoholic: directly pass through a 0.22μm filter membrane
Isooctane: needs to be concentrated by nitrogen blowing and then fixed to volume with methanol

Standard product management requirements

Stock solution (stored at -5℃, valid for 12 months)
Intermediate solution (stored at 0-5℃, valid for 6 months)
Working solution (stored at 0-5℃, valid for 3 months)

Method validation data

Precision requirement: The difference between repeated determination results is ≤20%, mainly based on:

Validation test of 6 food simulants
0.001-0.20mg/L linear range validation
Simultaneous detection capability validation of 4 compounds

Recommendations for application of standards

For CAS 84852-15-3 nonylphenol, it should be reported together with 104-40-5
Isooctane simulants require special attention to the recovery control of the concentration step
It is recommended to add matrix matching standards to each batch of testing

More samples: NB/T 47013.2-2015 DL/T 368-2010 JJG 21-2008

Sample only — not a preview of SN/T 5309-2021

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