GB/T 36700.5-2018 in English

VALID

Chemicals—Guidance on hazard classification to the aquatic environment—Part 5:Bioconcentration

Issued on:2018-09-17
Implemented on:2019-04-01
File Format:PDF
Delivery:Via email within 5 business days

Price(USD)： $310.00
$301.00

Standard No:	GB/T 36700.5-2018
Document status:	VALID
Title in English:	Chemicals—Guidance on hazard classification to the aquatic environment—Part 5:Bioconcentration
Title in Chinese:	化学品水生环境危害分类指导第5部分：生物富集
Language:	English
File Format:	Electronic (PDF)
Delivery:	Via email within 5 business days
Issued on:	2018-09-17
Implemented on:	2019-04-01
ICS Classification:	13.300-Protection against dangerous goods
Chinese Classification:	A80-Marking, packaging, transport and storage in general
Professional Classification:	GB-National Standard
Related Topics:	enriched sample enrichment enrichment of samples environment aquatic Tritium hazard hazards of biological products biohazard chemical environment biological sample hazard Molecular Biotechnology Environment pre-enriched sample biohazard Biohazard+ jug environmental organisms aquatic environment aquatic environment Sample enrichment instrument Sample Pre-enrichment Hazard Classification of Chemicals Guidance on Classification of Hazards to the Aquatic Environment Harm of enrichment enrichment hazard Bromine water hazard GBT36700.5 GB/T 36700.5-2018 Code of Classification and Labeling of Chemicals Part 28 Code of Classification and Labeling of Chemicals for the Aquatic Environment Potential chemical hazards and biological hazards of genetic engineering experiments metaboanalyst enrichment analysis Biological indicator Fujie Water microbial enrichment system pyramid biohazard classification GSVA enrichment analysis Microbial enrichment methods Vulcanization environment classification Bioanalysis of drinking water sample enrichment methods

《GB/T 36700.5-2018化学品水生环境危害分类指导第5部分：生物富集》由TC251（全国危险化学品管理标准化技术委员会）归口，主管部门为国家标准化管理委员会。

Introduction

Analysis of the core content of the standard

This part provides technical specifications for the evaluation of the bioconcentration potential of chemicals in the aquatic environment, focusing on two key parameters:

Bioconcentration Factor (BCF): reflects the distribution balance of chemicals between organisms and the aquatic environment
n-octanol-water partition coefficient (K_ow): characterizes the lipophilicity characteristics of chemicals

Bioconcentration Data Evaluation System

Data Type	Priority Level	Applicable Conditions	Precautions
Experimental Determination of BCF	Highest	GB/T 21800/21858 and other standard methods	Steady-state conditions need to be verified
Measured K_ow	Second priority	lgK_ow in the range of -2~8	Strong acid/base requires buffering
QSAR estimated value	Supplementary use	When data is missing	Model applicability needs to be verified

Key judgment threshold

Classification decision tree:

When BCF≥500, it is determined to have bioaccumulation potential
When lgK_ow≥4 and no measured BCF, it is presumed to have bioaccumulation potential
Special assessment is required for substances with molecular weight>700

Typical application case: A hydrophobic organic compound has a measured BCF=1200, which is directly determined to have aquatic environmental accumulation hazard; another substance is only measured with lgK_ow=4.2, and in the absence of metabolic data, it needs to be classified according to the conservative principle.

Technical evolution and implementation suggestions

Standard development background

This part inherits the OECD test guide system and forms a supporting technical document with GB30000.28. Main updates of the 2018 version:

Data processing principles for highly lipophilic substances (lgK_ow>6) are clarified
Evaluation methods for special substances such as surfactants are added
Weight of evidence approach is introduced to resolve data contradictions

Key points for implementation

Preferably, flow-through fish test (GB/T 21800) is used to obtain BCF data
Radioactive labeling data needs to correct for metabolite interference
Surfactants should be evaluated by subclasses
Regularly check the applicable domain of QSAR models

More samples: DL/T 368-2010 DL/T 5154-2012 JC/T 2453-2018

Sample only — not a preview of GB/T 36700.5-2018

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