GB/T 39884-2021 in English

Analysis of the standard technical framework

This standard establishes a complete detection technology system, the core of which includes:

In-depth analysis of the principle of the method

Based on the dual mechanism of chromatographic separation-mass spectrometry identification:

1. Methanol extraction: Ultrasonic-assisted extraction efficiency is more than 95%
2. GC-MS qualitative analysis: by retention time (±1%) and characteristic ion comparison (see Appendix B mass spectrum)
3. GC quantitative analysis: external standard single-point method (±30% concentration matching) or internal standard standard curve method (0.005-0.08mg/mL)

Key operating points

Recommendations for implementation of the standard

1. Laboratories should establish:

• Method validation plan (including LOD, linear range, etc.)
• Uncertainty assessment procedure (according to GB/T27418)

2. Pay attention to the following in actual application:

• Handling of interference from different matrices (it is recommended to add a purification step)
• Cross-validation of emerging synthetic cannabinoids