GB 31657.3-2022 in English
VALIDNational food safety standard—Determination of cephalosporins residues in bee products by liquid chromatography-tandem mass spectrometric method
- Issued on:2022-09-20
- Implemented on:2023-02-01
- File Format:PDF
- Delivery:Via email within 1~3 business days
$156.00
Introduction
1. Background and significance of the standard
GB31657.3-2022 "National Food Safety Standard for the Determination of Cephalosporin Residues in Bee Products by Liquid Chromatography-Tandem Mass Spectrometry" is a standard formulated for the detection of cephalosporin residues in bee products (including honey, royal jelly and royal jelly freeze-dried powder). This standard replaces the old version GB/T22942-2008, and is mainly optimized in terms of detection range, sensitivity and applicability.
2. Standard Technical Specifications
| Test Items | Test Methods | Scope of Application |
|---|---|---|
| Cephalosporin Drug Residues | Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) | Honey, Royal Jelly and Lyophilized Powder |
| Detection Sensitivity | The minimum detection limit is 0.5pg/kg to 20ng/kg | Applicable to trace analysis |
3. Experimental Procedures and Sample Preparation
Sample preparation:Take an appropriate amount of bee product samples and homogenize them according to standard requirements. For solid samples (such as royal jelly freeze-dried powder), they need to be dissolved and stirred in advance.
Extraction and purification: Solid phase extraction (SPE) is used to enrich and purify the target drugs in the sample. Use liquid chromatography-tandem mass spectrometry with specific chromatographic columns and mobile phase conditions for separation.
4. Preparation of standard solution and detection sensitivity
| Drug name | Standard stock solution concentration | Limit of quantitation (LOQ) |
|---|---|---|
| Cefoperazone | 400pg/mL | 8.0ng/kg |
| Cefoperazone | 400pg/mL | 20ng/kg |
5. Implementation suggestions
To ensure the effective implementation of the standard, it is recommended that:
- Laboratory equipment>Liquid chromatography-tandem mass spectrometer and related auxiliary equipment.
- Regularly calibrate the instrument and verify the accuracy of the method.
- Strengthen the professional training of testing personnel to ensure standardized operation.
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