GB/T 37641-2019 in English
VALIDDetermination of 2,3,5,4'-tetrahydroxystilbene-O-β-D-glucoside in cosmetics―High performance liquid chromatography
- Issued on:2019-06-04
- Implemented on:2020-01-01
- File Format:PDF
- Delivery:Via email within 1~3 business days
$156.00
《GB/T 37641-2019化妆品中2,3,5,4'-四羟基二苯乙烯-2-O-β-D-葡萄糖苷的测定 高效液相色谱法》由TC257（全国香料香精化妆品标准化技术委员会）归口，TC257SC2（全国香料香精化妆品标准化技术委员会化妆品分会）执行，主管部门为中国轻工业联合会。
Introduction
1. Standard Overview
GB/T 37641—2019 "High Performance Liquid Chromatography Method for the Determination of Stilbene Glycosides in Cosmetics" is a national standard of the People's Republic of China, which is used to determine the content of stilbene glycosides, the main characteristic ingredient of Polygonum multiflorum in cosmetics. This standard specifies the principles, reagents and materials, instruments and equipment, determination steps, result calculation and other contents of the qualitative and quantitative detection method of high performance liquid chromatography.
2. Background of Standard Formulation
Stilbene glycosides are an important natural stilbene compound with antioxidant and anti-inflammatory biological activities. In cosmetics, it is usually derived from Polygonum multiflorum extracts. In order to ensure product quality and safety, the national standard GB/T 37641—2019 came into being to standardize its detection method.
3. Comparison of standard frameworks
| Standard dimensions | GB/T 37641—2019 | USP (United States Pharmacopoeia) | PhEur (European Pharmacopoeia) |
|---|---|---|---|
| Scope of application | Determination of stilbene glycosides in cosmetics | Analysis of stilbene glycosides in pharmaceuticals and supplements | Analytical methods for European Pharmacopoeia reference materials |
| Detection principle | High performance liquid chromatography (HPLC) + UV detector | HPLC or UHPLC combined with MS/MS | HPLC combined with UV detection |
| Sensitivity | Detection limit: 2 mg/kg; Quantification limit: 7 mg/kg | LOD: 1 μg/mL | LOQ: 5 μg/mL |
4. Implementation suggestions
Applicable scenarios:
- Applicable to the detection of diphenylethylene glycosides in cosmetics such as shampoo and conditioner.
- It is recommended that manufacturers use this standard as part of quality control.
Operational suggestions:
- Prepare reagents and instruments in strict accordance with standard requirements to ensure that the purity of acetonitrile reaches chromatographic grade.
- During sample processing, pay attention to light-proof operation to avoid decomposition of diphenylethylene glycosides.
- It is recommended to use external standard method for quantification and calibrate the HPLC regularly.
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